NAD+ Dosage: How 250 mg and 500 mg Infusions Compare

When you look at NAD+ IV menus, the numbers vary widely, from small doses to very large ones spread over several days. At AuraWell, NAD+ is offered at 250 mg or 500 mg. Understanding how these doses differ helps you choose a sensible starting point.

Short answer: there is no research-established best dose of IV NAD+. A 250 mg infusion is shorter and a sensible starting point for most first-time patients. A 500 mg infusion takes longer and suits people who have tolerated NAD+ before. Your practitioner chooses the dose with you based on your health, goals and how you responded previously.

Why dose matters with NAD+

Unlike a hydration drip, NAD+ causes noticeable sensations when it enters the bloodstream too fast: chest tightness, nausea, cramping and flushing. The larger the dose, the longer it must run to stay comfortable. Dose therefore affects not just how much NAD+ you receive, but how long you spend in the chair and how the session feels.

250 mg

• A shorter appointment than 500 mg
• A gentler introduction for first-time patients
• Lets you and your nurse see how you tolerate NAD+
• A lower cost per session

500 mg

• A longer appointment, because the rate must stay slow
• Usually chosen by people who have had NAD+ before without difficulty
• A higher cost per session

Current prices for both doses are listed on our NAD+ IV therapy page, and the four-session package applies to any drip, including NAD+.

What the research says about dosing

Human studies of IV NAD+ are few and small, and they do not establish an ideal dose, frequency or number of sessions for any wellness goal. Higher doses have not been shown to produce better outcomes in healthy people. That is why we start conservatively and adjust based on your experience rather than a fixed protocol. Read NAD+ benefits and research for the bigger picture.

How your practitioner decides

1. Health screen. Your history, medications and any conditions that call for caution.
2. Your goals. What you hope to feel or achieve, and whether NAD+ is a reasonable way to pursue it.
3. Previous experience. How you tolerated any earlier infusions, including at other clinics.
4. Time available. A 500 mg infusion needs a longer block of time.

How often?

There is no proven schedule. Some people try a single session; others choose a short series and then review. We recommend deciding frequency after you have seen how your first infusion felt. See how often you can safely get IV therapy.

Comparing doses across clinics

Doses quoted elsewhere may be much higher and spread over consecutive days. Ask what the dose is based on, how long each session takes, who monitors you and what results are realistic. Bigger numbers do not mean better care. For different delivery methods, compare NAD+ injections versus IV.

Getting ready

Whatever dose you choose, preparation helps: eat beforehand, bring your supplement list and plan your time. Read how to prepare for your first NAD+ infusion and our NAD+ IV therapy guide.

What shapes your dose plan, step by step

There is no single right dose of NAD+. The plan is built around you and adjusted as you go.

1. Health screen. Your history, medications, blood pressure and heart rate are reviewed first. Some findings point to a lower dose or a different option.
2. Experience with NAD+. First-time recipients usually start at a lower dose so the team can see how you respond.
3. Your goal. A general wellness goal and a specific concern may lead to different suggestions, or to tests before any infusion.
4. How you tolerate the rate. Chest pressure, nausea, flushing or cramping usually ease when the drip slows. If they persist at a low rate, a higher dose is unlikely to be comfortable.
5. Your time. Higher doses run longer, so your schedule on the day matters.
6. Your response over sessions. Notes on sleep, energy and side effects help decide whether to stay at the same dose, adjust it or stop.

Who may start lower, and who should not have NAD+ at all for now

People who are often started on a lower dose

• First-time recipients and people who are sensitive to medications.
• Smaller adults or those with a lower body weight.
• People who felt uncomfortable during a previous infusion elsewhere.
• Those with a busy day who prefer a shorter appointment.

People who should wait or choose another option

• Anyone who is pregnant or breastfeeding.
• People with active cancer, until their oncology team has been consulted.
• People with significant heart, liver or kidney disease.
• Anyone with fever or an active infection on the day.

Questions to ask about your dose

• Why is this dose suggested for me rather than the other one?
• How long will the infusion take at this dose?
• What will we do if I feel side effects partway through?
• If I feel well, when would we consider a change?
• How many sessions before we review the plan together?

What the research does not cover yet

Dosing research for IV NAD+ is limited. Published studies are small and use different doses, rates and schedules, so they do not establish an ideal dose for wellness or show that a higher dose leads to better results. It is also unclear how dose relates to NAD+ levels inside tissues, and how long any rise lasts. Until better studies exist, starting conservatively and adjusting to how you respond is the careful approach.

To understand the molecule itself, read NAD+ versus NADH, and for habits that support your own NAD+ production between sessions, see natural ways to support NAD+. People from Woodbridge, Vaughan and Richmond Hill can discuss dosing in a screening visit with our nurse practitioner before any infusion is booked.

Keeping a dose diary between sessions

A short diary turns a vague impression into useful information. After each infusion, note the dose, how long it took, any sensations during the drip and what slowed or eased them. Over the following three days, rate your sleep, energy, focus and mood from 1 to 5, and record any side effects such as headache, nausea or tiredness. Bring the diary to your next appointment. Comparing two or three sessions side by side shows far more clearly than memory whether a dose suits you, whether a change is worth trying, or whether NAD+ is not adding enough to continue.

Not sure which dose to start with? Learn about NAD+ IV therapy in Woodbridge or call 905-207-7000 to book a screening visit at AuraWell Health, 4600 Hwy 7, Unit 105, Woodbridge, ON L4L 4Y7.